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Pragmatic trials are those that are designed to provide information for real-world clinical practice. They are typically characterized by a focus on practical aspects of the study design, including the recruitment process and consent, adherence, and the use of commonly available equipment.

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Pragmatic is a software company that offers a broad range of casino games on online gambling platforms. Pragmatic's iGaming solutions are utilized by the most reputable operators as well as land-based casinos. The company offers front-end site design tools, analysis tools and promotions, marketing, security payment systems, customer support and bug reporting. The company also offers an environment that is safe and secure with high-quality graphics, gameplay and security.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and participants from various geographical areas. This type of heterogeneity is essential for pragmatic trials to be valid, and it also helps to reduce bias in the results. A high degree of heterogeneity, however could cause issues with the trial design.

Pragmatic Play, one of the biggest players on the live casino market offers various classic table games like Blackjack and Roulette. The live studios of Pragmatic Play in Romania and Malta offer customers an authentic gambling experience, and a wide selection of virtual betting options. The company has also created numerous interactive game shows that make gambling online enjoyable. Some of these shows feature a live host, while others are hosted by famous personalities from the industry.

Mobile compatibility

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Pragmatic Play offers not only mobile-friendly slot machines but also table games and live casino. The company is licensed and regulated by several regulatory bodies, including the Malta Gaming Authority and UK Gambling Commission. The games of the company are protected by high-end encryption and its security team is on hand to assist players with any issues.

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Legality

Pragmatic Play is known for its top-notch games, and also for providing an outstanding user experience. The software is available on mobile devices and in a variety of languages. Despite its infancy it has established itself as a leading gaming platform for casinos. The latest releases include Wolves which is a five-reel video slot with a healthful RTP and stunning graphics. Its other notable titles are Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to mimic real-life situations and achieve maximum credibility externally. They are usually requested by practitioners and policy makers to inform their decision making. They can also be a great method of determining the causality between the intervention and its effects. However, they should not be used in lieu for the use of explanation studies.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis and pragmatic trials that inform the practice and policy decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic research study which includes the recruitment, design, and delivery of the intervention and its follow-up.

There is a positive trend in the number of pragmatic trials that have been published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the issue of pragmatism. It is important to keep in mind, however, that the majority of these studies were conducted in primary care settings.