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Pragmatic trials are those that are designed to inform real-world clinical practice. They are typically focused on practical aspects of the study design, such as the recruitment process and consent, adherence, and the use of standard equipment.

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A pragmatic trial that uses different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is essential for pragmatic trials to be reliable and reduce bias in results is also essential. A high degree of heterogeneity, however, can cause problems with the trial design.

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Legality

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The purpose of pragmatic trials is to mimic real-life scenarios and gain the highest level of validity externally. Usually, they are commissioned by policymakers and practitioners in order to guide their decisions. They can also be used to determine the causality of an intervention and its results. However, they should not be used in lieu for explanation trials.

The pragmatism concept is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which confirm the validity of a physiological or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also proposed an approach to pragmatic trials, dubbed PRECIS.2 This tool sought to define the characteristics of a practical trial, including the recruitment process, the design and implementation of the intervention, and 프라그마틱 슬롯 무료 프라그마틱 무료 프라그마틱 슬롯 체험 (click the up coming web page) follow-up.

There is a growing increase in the number pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health science community is becoming more acquaint to the subject of pragmatic thinking. However, it is important to note that the majority of these trials were conducted in primary care settings.