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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often characterized as focusing on practical aspects of designing a study which include the recruitment process and consent, adhering and the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from different geographic areas. This type of heterogeneity which is essential for pragmatic trials to be reliable and reduce bias in results is also essential. However too much heterogeneity could cause problems with the design of the trial.

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The goal of pragmatic trials is to mimic real-life scenarios and to achieve maximum validity externally. They are typically commissioned by policy makers and practitioners to guide their decision-making. They also provide a useful way to identify the causality between an intervention and its results. However, they should not be used as a substitute for 프라그마틱 정품확인방법 explanation studies.

The pragmatism idea is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the clinical or physiological hypothesis as well as pragmatic trials, which guide policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the traits of a practical study that includes the recruitment, design, and delivery of the intervention and its follow-up.

There is a positive increase in the number of pragmatic trials that have been published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs) produced 34 articles, as shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to note that the majority of these studies were conducted in primary care settings.