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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are typically described as focusing on practical aspects of design, including the recruitment process and consent, adhering and the use routinely available equipment.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and had participants from different geographic areas. This kind of heterogeneity, 무료슬롯 프라그마틱 that is crucial for a pragmatic trial to be valid and reduce bias in results, is also necessary. A high degree of heterogeneity, however, can cause problems with the trial design.
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Pragmatic trials are designed to replicate real-world situations and have the highest external validity. Usually, they are commissioned by policymakers and practitioners to help inform their decisions. They can be used to determine the cause-effect relationship of an intervention with its outcomes. However, they should not be used to replace the need for explanation studies.
The concept of pragmatism is controversial, and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which confirm the validity of a physiological or clinical hypothesis, as well as pragmatic trials, which inform the decision-making process for policy and practice. They also proposed an approach to pragmatic trials, called PRECIS.2 This tool attempted to define the characteristics of a pragmatic trial which includes recruitment, design and delivery of the intervention, and 프라그마틱 데모 monitoring.
There is a growing trend in the number of pragmatic trials that have been published. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary care settings.