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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often characterized by a focus on the practical aspects of study design, such as recruitment and consent in adherence, as well as the use of standard equipment.

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A pragmatic study that involves different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is essential for pragmatic trials to be reliable and to reduce bias in the results is also essential. However excessive heterogeneity could cause issues with the design of the trial.

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The purpose of pragmatic trials is to replicate real-life scenarios and 프라그마틱 슬롯 무료 to achieve maximum validity externally. Usually, 프라그마틱 무료체험 슬롯버프 they are ordered by policymakers and practitioners to help inform their decisions. They are also a good method to determine the cause-effect relationship between an intervention and its outcomes. However, they should not be used to substitute for explanatory studies.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials can replace tests for explanations or if they are an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm a physiological or clinical hypothesis, and pragmatic trials, which inform the practice and policy decisions. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the features of a practical trial that include recruitment, design and delivery of the intervention, as well as the follow-up.

The number of pragmatic trials is growing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) produced 34 articles, which are shown in red in Figure 2. This is an indication that the health science community is becoming increasingly sensitized to the issue of pragmatism. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.