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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often described by their focus on practical aspects of design that include the recruitment and consent process, as well as adherence and the use routinely available equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and had participants from different geographical regions. This type of heterogeneity, which is vital for pragmatic trials to be valid and to reduce bias in the results, is also necessary. However, too much heterogeneity can lead to problems with the design of the trial.
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Pragmatic trials aim to mimic real-world situations and 프라그마틱 게임 정품 (click here for info) have the highest external validity. They are usually commissioned by policy makers and practitioners to guide their decision-making. They can also be used to determine the causality of an intervention and its effects. However, they shouldn't be used to substitute for the use of explanation studies.
The pragmatism idea is controversial and there are concerns regarding whether pragmatic trials could be used to replace explanation tests or if they are an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also suggested the framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the characteristics of a pragmatic study which includes the recruitment process, the design and implementation of the intervention, as well as the follow-up.
There is a growing increase in the number of pragmatic trials that are published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health sciences community is becoming more acquaint to the subject of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary-care settings.