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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are typically focused on practical aspects of the study design, such as recruitment and consent in adherence, as well as the use of routinely available equipment.

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A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for pragmatic trials to be valid and helps reduce the chance of bias in the results. However, too much heterogeneity, can cause problems with the trial design.

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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are usually commissioned by policymakers and practitioners in order to inform their decisions. They can also be a great method to determine the causal relationship between an intervention and its outcomes. However, they should not be used in lieu for the use of explanation trials.

The pragmatism concept is controversial, 프라그마틱 환수율 and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis, and pragmatic trials that inform the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic study, including recruitment, design, delivery of the intervention and follow-up.

There is an encouraging increase in the number pragmatic trials that have been published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) produced 34 articles, which are shown in red in Figure 2. This is a sign that the health sciences community is becoming more sensitive to the subject of pragmatics. It is important to note that the majority were conducted in primary-care settings.