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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are typically described by their focus on practical aspects of study design, including the recruitment process and consent, adhering and the use of standard equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and participants from various geographical areas. This kind of heterogeneity is necessary for pragmatic trials to be valid and helps to reduce the chance of bias in the results. However, too much heterogeneity can cause problems with the design of the trial.

Pragmatic Play, one of the biggest players on the live casino market offers various classic table games, including Blackjack and Roulette. The company's live studios in Romania and Malta offer an authentic gambling experience for customers, as well as a wide range of virtual betting options. The company also hosts a variety of games that make online gambling more exciting and interactive. Some of these shows have live hosts, whereas others are hosted by famous personalities from the industry.

Mobile compatibility

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Pragmatic Play offers not only mobile-friendly slot machines but also tables games and live casinos. The company is licensed and regulated by a variety of governing bodies that include the Malta Gaming Authority and UK Gambling Commission. The games are supported by high-end encryption and the security team is always on hand to help players with any issues they might have.

Pragmatic Play's slot games are a hit with newbies as well as experienced players. They feature modern graphics and traditional themes. They offer a range of bonus rounds and paylines, and many offer progressive jackpots. They are also not particularly volatile, so you can expect to enjoy a long gaming session with them.

Pragmatic Play offers a large variety of games you can play at no cost before deciding whether you want to purchase them. These games are free and can be played on any device, including desktops, tablets and even smartphones. They are simple to navigate, and you can play them from anywhere with an internet connection. Some Pragmatic Play sites even allow players to test their skills on the go using the practice mode. This can help you get familiar with the game rules and features before playing for real money.

Legality

Pragmatic Play is known for its top-quality games and also for providing an outstanding user experience. Its software is accessible on mobile devices as well as in various languages. Despite its infancy it has established itself as a top gaming platform for casinos. The latest releases include Wolves which is a five-reel video slot with a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are typically ordered by policymakers and practitioners in order to inform their decisions. They also provide a useful method to determine the causal relationship between an intervention and its results. They should not, however, be used to replace explanatory studies.

The idea of pragmatism is controversial and there are concerns about whether pragmatic trials should replace tests for explanations or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the clinical or physiological hypothesis and pragmatic trials, which guide policy and practice decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic study, including the recruitment, design, and delivery of the intervention and follow-up.

The number of pragmatic trials is growing. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs), yielded 34 articles, shown in red in Figure 2. This is an indication that the health sciences community is becoming more sensitive to the issue of pragmatic thinking. However, it is important to remember that the majority of these studies were conducted in primary care settings.