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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are usually characterized by a focus on practical aspects of the study design, such as the recruitment and consent process as well as adherence to the use of routinely available equipment.

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A pragmatic study that involves a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, that is crucial for a pragmatic trial to be valid and reduce bias in results is also essential. Too much heterogeneity, however can result in problems with the design of the trial.

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The goal of pragmatic trials is to simulate real-life situations and achieve maximum validity externally. Usually, they are requested by practitioners and policymakers to guide their decisions. They can also be used to assess the causal relationship between an intervention with its outcomes. However, they should not be used in lieu for explanatory studies.

The pragmatism idea is controversial and there are concerns regarding whether pragmatic trials could replace explanatory tests or if they are an addition to them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform the decision-making process for policy and 프라그마틱 정품인증 practice. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic study which includes recruitment, design, delivery of the intervention, and follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs) produced 34 articles, as shown in red in Figure 2. This indicates that the health sciences community is becoming more acquaint to the subject of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary-care settings.