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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often characterized as a focus on the practical aspects of study design which include the recruitment and consent process, as well as adherence and the use of standard equipment.

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A pragmatic trial that uses different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, 프라그마틱 무료 슬롯 which is essential for pragmatic trials to be valid and lessen the chance of bias is also essential. Too much heterogeneity, however, can cause problems with the trial design.

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Pragmatic Play has earned a name for itself by providing top-notch games and an exceptional user experience. The software is available on mobile devices and in multiple languages. Despite its relatively young age it has already established itself as a top casino gaming platform. Wolves is one of the most recent releases which is a five-reel slot machine with a hefty RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are typically commissioned by practitioners and policy makers to inform their decision making. They also provide a useful method to determine the causality between the intervention and its effects. However, they should not be used to replace explanatory studies.

The concept of pragmatism is controversial, and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which support the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also proposed a framework for pragmatic trials, called PRECIS.2 This tool sought to define the features of a pragmatic trial which includes the recruitment process, the design and delivery of the intervention, and the follow-up.

The number of pragmatic trials is growing. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs), yielded 34 articles, shown in red in Figure 2. This is a sign that the health science community is becoming more acquaint to the subject of pragmatic thinking. It is important to note that the majority were conducted in primary-care settings.