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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often characterized by their focus on practical aspects of designing a study which include recruitment and consent, adherence and the use routinely available equipment.
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A pragmatic study that involves different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is essential for a pragmatic trial to be reliable and to reduce bias in the results, is also necessary. A high degree of heterogeneity, however, can cause problems with the design of the trial.
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Pragmatic Play has earned a reputation for providing top-quality games and an outstanding user experience. The software is available on mobile devices as well as in various languages. It has established itself as one of the leading casino gaming platforms despite its relative youth. The latest releases include Wolves which is a five-reel video slot with a healthy RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.
Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are usually requested by policy makers and practitioners to aid in their decision-making. They can also be used to assess the cause-effect relationship of an intervention with its outcomes. However, they should not, be used to replace explanatory studies.
The pragmatism idea is controversial and there are concerns about whether pragmatic trials can be used to replace explanation tests or if they should be an addition to them. Schwartz and 프라그마틱 환수율 Lellouch1 made a distinction between explanatory studies, which prove the validity of a physiological or clinical hypothesis, and pragmatic trials, which inform the practice and policy decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the traits of a pragmatic study that includes recruitment, design, implementation of the intervention and its follow-up.
There is a growing increase in the number pragmatic trials published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs), yielded 34 articles, shown in red in Figure 2. This is a sign that the health science community is becoming more sensitive to the issue of pragmatism. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.
