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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often described by their focus on practical aspects of designing a study that include recruitment and consent, 프라그마틱 슬롯 추천 adherence and the use of standard equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and had participants from different geographic areas. This kind of heterogeneity, that is crucial for pragmatic trials to be reliable and lessen the chance of bias is also essential. However excessive heterogeneity could lead to issues with the design of the trial.

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The purpose of pragmatic trials is to mimic real-life situations and achieve maximum validity externally. They are usually requested by practitioners and policy makers to guide their decision-making. They can also be used to assess the causality of an intervention and its results. They should not, however be used to replace explanatory studies.

The pragmatism concept is controversial and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 made a distinction between explanatory studies, which prove the physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in the decision-making process for policy and practice. They also suggested a framework for pragmatic trials, called PRECIS.2 This tool sought to define the elements of a practical trial which includes the recruitment process, the design and delivery of the intervention, and monitoring.

There is a growing increase in the number pragmatic trials that have been published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. However, it is important to remember that the majority of these studies were conducted in primary care settings.