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Pragmatic trials are those that are designed to inform real-world clinical practice. They are usually characterized by a focus on practical aspects of the study design, such as the recruitment process and consent in adherence, as well as the use of standard equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and had participants from different geographical regions. This type of heterogeneity which is vital for pragmatic trials to be reliable and lessen the chance of bias is also essential. Too much heterogeneity, however can result in problems with the design of the trial.
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Legality
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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are usually commissioned by policy makers and practitioners to guide their decision-making. They also provide a useful method to determine the causal relationship between an intervention and its results. However, they shouldn't be used in lieu for explanatory studies.
The pragmatism concept is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the validity of a clinical or 프라그마틱 정품 physiological hypothesis as well as pragmatic trials, which inform the policy and practice of. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the traits of a practical study that includes recruitment, design, implementation of the intervention and follow-up.
There is a positive trend in the number of pragmatic trials that have been published. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) resulted in 34 articles, shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.