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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are typically characterized by a focus on practical aspects of the study design, including the recruitment process and consent, adherence, and the use of commonly available equipment.

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A pragmatic study that involves various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be valid, and it also helps to reduce bias in the results. However, too much heterogeneity, can cause problems with the design of the trial.

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Pragmatic trials are designed to replicate real-world situations and have the highest external validity. Usually, they are ordered by policymakers and practitioners to guide their decisions. They are also a good method to determine the causal relationship between the intervention and its effects. They should, however, not be used to replace explanation studies.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the clinical or physiological hypothesis as well as pragmatic trials, 프라그마틱 정품 확인법 순위 (click through the following internet site) which inform the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the elements of a pragmatic study that includes recruitment, design, implementation of the intervention and follow-up.

The number of pragmatic trials is growing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This indicates that the health science community is becoming increasingly sensitized to the subject of pragmatism. It is important to remember that the majority of these trials were conducted in primary care settings.