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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are typically described by their focus on practical aspects of design which include recruitment and consent, adherence and the use routinely available equipment.
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A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, that is crucial for pragmatic trials to be reliable and to reduce bias in the results is also essential. However, too much heterogeneity can cause problems with the design of the trial.
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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are typically commissioned by policy makers and practitioners to aid in their decision-making. They can be used to determine the causality of an intervention with its outcomes. They should, however, not, be used to replace the need for explanation studies.
The concept of pragmatism is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, 프라그마틱 환수율 which validate the clinical or physiological hypothesis, and pragmatic trials that inform policy and practice decisions. They also proposed an approach to pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a pragmatic study, including the recruitment process, the design and delivery of the intervention, as well as monitoring.
The number of pragmatic trials is growing. A recent Medline search using the keywords naturalistic and 프라그마틱 슬롯 체험 pragmatic, limited to controlled trials that are randomized (RCTs) produced 34 articles, which are shown in red in Figure 2. This is an indication that the health sciences community is becoming more sensitive to the subject of pragmatism. It is important to note that the majority of these studies were conducted in primary care settings.