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Pragmatic trials are studies designed to inform the practice of clinical trials in real life. They are often characterized by a focus on the practical aspects of study design, including the recruitment process and consent in adherence, as well as the use of commonly available equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and had participants from different geographical regions. This kind of heterogeneity is required for practical trials to be valid and also helps to reduce the chance of bias in the results. However, too much heterogeneity, can cause problems with the design of the trial.
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The aim of pragmatic trials is to replicate real-life scenarios and to achieve the highest level of validity externally. They are typically ordered by policymakers and practitioners in order to guide their decisions. They can also be used to determine the cause-effect relationship of an intervention with its outcomes. However, they should not be used to substitute for explanation studies.
The pragmatism idea is controversial, and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which support the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform the practice and policy decision-making. They also proposed a framework called PRECIS for 프라그마틱 슬롯 조작 데모 (Socialmphl.Com) pragmatic trials.2 This tool attempted to define the elements of a practical study that includes recruitment, design, delivery of the intervention and its follow-up.
There is an encouraging increase in the number pragmatic trials that have been published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming more acquaint to the subject of pragmatics. It is important to remember that the majority were conducted in primary-care settings.