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Pragmatic trials are studies designed to inform real-world clinical practice. They are often described as focusing on practical aspects of design that include the recruitment and consent process, as well as adherence and the use of standard equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed different investigators and had participants from different geographic areas. This type of heterogeneity, that is crucial for a pragmatic trial to be reliable and 프라그마틱 추천 lessen the chance of bias, 프라그마틱 정품 확인법 is also necessary. However excessive heterogeneity could cause problems with the design of the trial.
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The goal of pragmatic trials is to simulate real-life scenarios and gain maximum credibility externally. Usually, they are requested by practitioners and policymakers to guide their decisions. They can also be a great method of determining the causal relationship between the intervention and its effects. However, they should not, be used to replace explanation studies.
The concept of pragmatism is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which prove the validity of a physiological or clinical hypothesis, and pragmatic trials that aid in policy and practice decision-making. They also proposed a framework for pragmatic trials, dubbed PRECIS.2 This tool sought to define the characteristics of a pragmatic study which includes the recruitment process, the design and implementation of the intervention, and follow-up.
There is a growing increase in the number of pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs), yielded 34 articles, shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary care settings.
