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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are often characterized by a focus on the practical aspects of the study design, such as the recruitment process and consent, adherence, and the use of routinely available equipment.
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A pragmatic trial that uses various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, that is crucial for a pragmatic trial to be valid and to reduce bias in the results, is also necessary. Too much heterogeneity, however can result in problems with the trial design.
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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are usually commissioned by policymakers and practitioners to guide their decisions. They are also a good method of determining the causal relationship between the intervention and its effects. However, they shouldn't be used as a substitute for the use of explanation studies.
The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the clinical or 프라그마틱 정품인증 슬롯 조작, Https://Scientific-Programs.Science/, physiological hypothesis and pragmatic trials that inform policy and practice decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the elements of a pragmatic study, including recruitment, design, delivery of the intervention and follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs) resulted in 34 articles, as shown in red in Figure 2. This indicates that the health sciences community is becoming more sensitive to the subject of pragmatism. It is important to note, 프라그마틱 슬롯버프 무료체험 (simply click the following internet site) however, that the majority were conducted in primary care settings.
