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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are usually characterized by a focus on practical aspects of the study design, such as recruitment and consent in adherence, as well as the use of commonly available equipment.
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A practical trial that employs a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for pragmatic trials to be valid and reduce bias in results is also essential. A high degree of heterogeneity, however, can cause problems with the trial design.
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The purpose of pragmatic trials is to mimic real-life scenarios and to achieve maximum credibility externally. They are usually commissioned by policymakers and practitioners in order to inform their decisions. They are also a good method to determine the causality between an intervention and its results. They should not, however, be used to replace explanatory studies.
The concept of pragmatism is controversial and there are concerns regarding whether pragmatic trials could be used to replace explanation tests or if they should serve as an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove the clinical or physiological hypothesis and pragmatic trials that inform the practice and policy decisions. They also proposed the framework for 프라그마틱 정품 사이트 pragmatic trials, 프라그마틱 정품 확인법 dubbed PRECIS.2 This tool sought to define the characteristics of a practical trial which includes the recruitment process, the design and delivery of the intervention, as well as monitoring.
The number of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, 프라그마틱 슬롯 무료체험 limited to randomized controlled trials (RCTs) produced 34 articles, shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to note that the majority of these studies were conducted in primary care settings.