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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are typically characterized by a focus on the practical aspects of the study design, such as the recruitment process and consent as well as adherence to the use of standard equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and had participants from various geographical areas. This kind of heterogeneity, that is crucial for a pragmatic trial to be reliable and lessen the chance of bias is also essential. A high degree of heterogeneity, however, can cause problems with the design of the trial.

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Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are usually requested by practitioners and policymakers to guide their decisions. They can also be used to determine the cause-effect relationship of an intervention and its effects. However, they shouldn't be used as a substitute for explanation trials.

The pragmatism idea is controversial and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove a physiological or clinical hypothesis and pragmatic trials, which guide the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a practical study that includes recruitment, 프라그마틱 데모 슬롯 환수율 (Allyourbookmarks.Com) design, implementation of the intervention and follow-up.

There is a positive increase in the number of pragmatic trials that have been published. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the issue of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary care settings.