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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are usually characterized by a focus on practical aspects of the study design, such as recruitment and consent, adherence, and the use of standard equipment.

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A pragmatic study that involves various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity that is crucial for a pragmatic trial to be reliable and to reduce bias in the results is also essential. However excessive heterogeneity could lead to issues with the design of the trial.

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The aim of pragmatic trials is to mimic real-life scenarios and gain maximum validity externally. They are usually ordered by policymakers and practitioners to guide their decisions. They can be used to determine the causal relationship between an intervention and its effects. However, they shouldn't be used in lieu for the use of explanation trials.

The pragmatism idea is controversial and there are concerns regarding whether pragmatic trials could replace explanatory tests or if they should serve as a complement to them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also proposed the framework for pragmatic trials, which they called PRECIS.2 This tool was designed to define the characteristics of a pragmatic study, including recruitment, design and delivery of the intervention, as well as follow-up.

The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and 프라그마틱 슬롯 조작 공식홈페이지 (Socialclubfm.Com) pragmatic, limited to controlled trials randomized to control (RCTs) resulted in 34 articles, shown in red in Figure 2. This indicates that the health science community is becoming more sensitive to the issue of pragmatism. It is important to keep in mind that the majority were conducted in primary-care settings.