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Pragmatic trials are studies designed to provide information for the real-world practice of clinical. They are often described as a focus on the practical aspects of study design which include the recruitment and consent process, as well as adherence and the use of standard equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used different investigators and had participants from different geographical regions. This type of heterogeneity which is vital for a pragmatic trial to be reliable and reduce bias in results is also essential. A high degree of heterogeneity, however can result in problems with the trial design.
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Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. They are usually requested by practitioners and policymakers in order to guide their decisions. They also provide a useful method to determine the causality between an intervention and its outcomes. However, they shouldn't be used to substitute for the use of explanation trials.
The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should be used to replace explanation tests or if they are a complement to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove a physiological or clinical hypothesis and pragmatic trials, which inform the practice and policy decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic study that includes recruitment, 프라그마틱 슬롯 design, implementation of the intervention, and follow-up.
There is a positive trend in the number of pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health science community is becoming more acquaint to the issue of pragmatics. It is important to note, however, that the majority were conducted in primary-care settings.